Clinically validatedformulationsfor real results
Every ingredient in the OneOral kit exists because
clinical evidence demanded it. Nothing more.
From our formulations to our protocols, we don't guess. Every decision is backed by peer-reviewed research and clinical trials.
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Built on
CAMBRA
OneOral is the first subscription platform designed around CAMBRA —
the gold standard in preventive dentistry, developed at UCSF.4
All five clinical interventions, in one at-home system.
5 mechanisms
every pathway of tooth decay — targeted in one integrated system
1 visit
per 2 years — that's the goal. OneOral gets you to CAMBRA low-risk
Everyone else treats the symptom.
We eliminate the cause.
Most oral care is the same whitening paste in a different box. OneOral uses CAMBRA to identify why you get cavities — bacterial load, pH imbalance, dry mouth, diet — then attacks every single pathway at once. Antibacterial reset. pH elevation. Bacterial starvation. Dual remineralization. Enamel regeneration. Nothing else comes close.
Mechanism 01
Antibacterial Reset
0.2% sodium hypochlorite eliminates S. mutans and Lactobacillus —
the acid-producing bacteria behind every cavity.
elevated pH
alkaline enough to make bacterial survival impossible
90 days
full antibacterial reset to rebalance your oral microbiome
Clinically validated. Mouth-safe.
Sodium hypochlorite is a clinically validated antimicrobial used in medical settings, carefully calibrated to 0.2% for safe, effective daily oral use. It doesn't just reduce bacteria — it disrupts the colony at the source.
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Mechanism 02
pH Elevation
Below pH 5.5, your enamel dissolves. Many mouthwashes
are mildly acidic. Ours is alkaline by design — above pH 8.
5.5
the critical pH threshold — we keep you above it, always
elevated pH
daily maintenance rinse — alkaline protection around the clock
Mechanism 03
Bacterial Starvation
Xylitol isn't a sweetener. It's a metabolic trap.
6–10g/day
therapeutic dose delivered — far beyond trace amounts in grocery store gum
p < 0.00001
statistical significance across meta-analysis of 7 clinical trials1
A futile cycle
S. mutans absorbs xylitol but can't metabolize it. The bacteria waste energy in a loop until they starve. At 22–25% concentration, our rinses deliver xylitol at doses that actually work — not the marketing doses you find on store shelves.
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Mechanism 04
Dual Remineralization
Most products protect. This one rebuilds.
1100ppm
fluoride — the clinically effective level for daily enamel protection
2.51x
higher caries prevention vs. placebo in nHAp meta-analysis2
Two materials. One formula.
Nano-hydroxyapatite fills micro-defects and rebuilds lost enamel structure. Fluoride strengthens the repaired surface and locks minerals in place. Most products use one or the other. We use both.
Mechanism 05
Enamel Regeneration
Reverse early decay. Without a drill.
93%
6-year success rate treating early caries lesions, dentist-applied3
P11-4
self-assembling peptide that triggers natural enamel regeneration from within
Curodont Repair
Not a coating — actual structural repair. A self-assembling peptide matrix, applied by a licensed dentist, that triggers your tooth's own regeneration process. Peer-reviewed, with six-year follow-up data. Available as a future add-on through a OneOral telehealth referral — not part of the current at-home kit.
By combining five validated mechanisms into one protocol, we don't just clean your teeth — we change the biology of your mouth to dramatically reduce your cavity risk.
References
- Xylitol caries prevention — meta-analysis, J Nat Sci Biol Med (PMC5320817).
- Nano-hydroxyapatite vs. placebo caries prevention — meta-analysis, Canadian J Dental Hygiene (PMC8641555).
- Curodont (P11-4) early-caries treatment, 6-year follow-up — Alkilzy et al., J Dent Res, 2018. Dentist-applied; offered via OneOral telehealth referral, not part of the at-home kit.
- CAMBRA (Caries Management By Risk Assessment) — Featherstone JDB et al., developed at UCSF.
Statistics describe published clinical research on the active ingredients used in OneOral formulations. Individual results vary. OneOral at-home products are not a substitute for professional dental care.